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Since multiaxial stresses can develop in trabecular bone during falls and at bone-implant interfaces, multiaxial strength behavior is of fundamental relevance to a number of orthopaedic problems. Building on the work of other student researchers in the lab who developed a 3D multiaxial failure criterion for human trabecular bone, the goal of my research is to understand the mechanisms of trabecular multiaxial failure and subsequently explain the biomechanical link between bone turnover and strength. This is widely considered a critical element of bone quality, and may play a role in osteoporosis diagnosis and treatment assessment, since the use of DXA in standard medical practice has been shown to be insufficient in explaining large reductions in fracture rates after anti-resorptive drug treatement. My work will include the use of high-resolution micro-CT based finite element (FE) analysis and mechanical testing of trabecular bone cores from control and anti-resorptive drug treated groups. Combining the FE and experimental approach enables separation of drug treatment effects on the microstructure versus the tissue material properties of the bone.